Vaccination against type 1 diabetes

Childhood vaccination and type 1 diabetes.

BACKGROUND A link between childhood vaccinations and the development of type 1 diabetes has been proposed. METHODS We evaluated a cohort comprising all children born in Denmark from January 1, 1990, through December 31, 2000, for whom detailed information on vaccinations and type 1 diabetes was available. Using Poisson regression models, we estimated rate ratios according to vaccination statu...

Thymic self-antigens for the design of a negative/tolerogenic self-vaccination against type 1 diabetes.

Before being able to react against infectious nonself-antigens, the immune system has to be educated in the recognition and tolerance of neuroendocrine proteins and this critical process takes place only in the thymus. The development of the autoimmune diabetogenic response results from a thymus dysfunction in programing central self-tolerance to pancreatic insulin-secreting islet beta cells, l...

Can we vaccinate against Type 1 diabetes?

Vaccination is the administration of antigenic material to stimulate the immune system to develop adaptive immunity to a disease. As the most successful prophylactic in medical history, there is now an emerging interest as to whether vaccination can be applied in autoimmune and inflammatory conditions. These are diseases of failed immune regulation; vaccination in this context aims to exploit t...

Neonatal Bacille Calmette-Guerin vaccination and type 1 diabetes.

T ype 1 diabetes is a genetic disorder that is associated with the early development of autoimmunity against islet -cells (1). The a priori genetically determined risk for type 1 diabetes is modified by mostly unknown environmental factors that are thought to contribute to the increasing incidences of childhood diabetes in the last decade. Changes in exposure to environment are also discussed a...

Autoantibodies against multiple tissues in type 1 diabetes.